Homocysteine and its thiolactone-mediated modification of fibrinogen affect blood platelet adhesion

Mechanism action of homocysteine and its thiolactone in haemostasis system

The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease.

Accumulating evidence suggests that homocysteine (Hcy) metabolite, the thioester Hcy-thiolactone, plays an important role in atherothrombosis. Hcy-thiolactone is a product of an error-editing reaction in protein biosynthesis which forms when Hcy is mistakenly selected by methionyl-tRNA synthetase. The thioester chemistry of Hcy-thiolactone underlies its ability to from isopeptide bonds with pro...

Commercial Extract from Aronia as a Modulator of Adhesive Properties of Fibrinogen Treated with Homocysteine and Its Thiolactone in Vitro

Research has confirmed the positive effect of berries of Aronia melanocarpa on the cardiovascular system. The protective effects of polyphenol-rich extract from berries of A. melanocarpa against changes in biological properties of fibrinogen were studied. In in vitro model of hyperhomocysteinemia the capability of fibrinogen to interact with human blood platelets was measured by platelet adhesi...

of platelet aggregation . Fibrinogen mediated activation

diagnosed by morphological, cytochemical, immunological, and ultrastructural methods.' Following remission induction with daunorubicin, vincristine, prednisolone, and L-asparaginase she received maintenance treatment with methotrexate, 6 mercaptopurine, cytosine arabinoside, vincristine, and prednisolone for 12 months before this was stopped due to neutropenia. She remained well until August 19...

Urinary excretion of homocysteine-thiolactone in humans.

BACKGROUND A metabolite of homocysteine (Hcy), the thioester Hcy-thiolactone, has been implicated in coronary heart disease in humans. Because inadvertent reactions of Hcy-thiolactone with proteins can lead to cell and tissue damage, the ability to detoxify or eliminate Hcy-thiolactone is essential for biological integrity. We examined the hypothesis that the human body eliminates Hcy-thiolacto...